Complement dysregulation and disease: from genes and proteins to diagnostics and drugs

SR de Cordoba, A Tortajada, CL Harris, BP Morgan - Immunobiology, 2012 - Elsevier
During the last decade, numerous studies have associated genetic variations in complement
components and regulators with a number of chronic and infectious diseases. The functional
characterization of these complement protein variants, in addition to recent structural
advances in understanding of the assembly, activation and regulation of the AP C3
convertase, have provided important insights into the pathogenic mechanisms involved in
some of these complement related disorders. This knowledge has identified potential targets …