Eculizumab for dense deposit disease and C3 glomerulonephritis

AS Bomback, RJ Smith, GR Barile… - Clinical Journal of the …, 2012 - journals.lww.com
Results The subjects included three patients with dense deposit disease (including one
patient with recurrent dense deposit disease in allograft) and three patients with C3
glomerulonephritis (including two patients with recurrent C3 glomerulonephritis in allograft).
Genetic and complement function testing revealed a mutation in CFH and MCP in one
subject each, C3 nephritic factor in three subjects, and elevated levels of serum membrane
attack complex in three subjects. After 12 months, two subjects showed significantly reduced …