[HTML][HTML] Molecular mechanisms of complement evasion: learning from staphylococci and meningococci
Nature reviews Microbiology, 2010•nature.com
The complement system is a crucial component of the innate immune response in humans.
Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how
these bacteria escape complement-mediated killing. In addition, new structural data have
provided detailed insights into the molecular mechanisms of host defence mediated by the
complement system and how bacterial proteins interfere with this process. This information
is fundamental to our understanding of bacterial pathogenesis and may facilitate the design …
Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how
these bacteria escape complement-mediated killing. In addition, new structural data have
provided detailed insights into the molecular mechanisms of host defence mediated by the
complement system and how bacterial proteins interfere with this process. This information
is fundamental to our understanding of bacterial pathogenesis and may facilitate the design …
Abstract
The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.
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