Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene
H Seitz, N Youngson, SP Lin, S Dalbert, M Paulsen… - Nature …, 2003 - nature.com
H Seitz, N Youngson, SP Lin, S Dalbert, M Paulsen, JP Bachellerie, AC Ferguson-Smith…
Nature genetics, 2003•nature.comMicroRNAs (miRNAs) are an abundant class of RNAs that are∼ 21–25 nucleotides (nt)
long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA
interference, RNAi) depending on the degree of complementarity with their targets. Here we
show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes
expressed from the maternally inherited chromosome and antisense to a retrotransposon-
like gene (Rtl1) expressed only from the paternal allele.
long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA
interference, RNAi) depending on the degree of complementarity with their targets. Here we
show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes
expressed from the maternally inherited chromosome and antisense to a retrotransposon-
like gene (Rtl1) expressed only from the paternal allele.
Abstract
MicroRNAs (miRNAs) are an abundant class of RNAs that are ∼21–25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.
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