[HTML][HTML] Estrogen-related receptor γ is a key regulator of muscle mitochondrial activity and oxidative capacity
SM Rangwala, X Wang, JA Calvo, L Lindsley… - Journal of Biological …, 2010 - ASBMB
Estrogen-related receptor γ (ERRγ) regulates the perinatal switch to oxidative metabolism in
the myocardium. We wanted to understand the significance of induction of ERRγ expression
in skeletal muscle by exercise. Muscle-specific VP16ERRγ transgenic mice demonstrated
an increase in exercise capacity, mitochondrial enzyme activity, and enlarged mitochondria
despite lower muscle weights. Furthermore, peak oxidative capacity was higher in the
transgenics as compared with control littermates. In contrast, mice lacking one copy of ERRγ …
the myocardium. We wanted to understand the significance of induction of ERRγ expression
in skeletal muscle by exercise. Muscle-specific VP16ERRγ transgenic mice demonstrated
an increase in exercise capacity, mitochondrial enzyme activity, and enlarged mitochondria
despite lower muscle weights. Furthermore, peak oxidative capacity was higher in the
transgenics as compared with control littermates. In contrast, mice lacking one copy of ERRγ …