Apolipoprotein A–V modulates multiple atherogenic mechanisms in a mouse model of disturbed clearance of triglyceride-rich lipoproteins
I Grosskopf, A Shaish, A Afek, S Shemesh, D Harats… - Atherosclerosis, 2012 - Elsevier
OBJECTIVE: Apolipoprotein A–V plays an important role in reducing plasma triglyceride
levels. We hypothesized that expression of apoA–V would inhibit atherogenesis in apoE−/−
mice fed chow diet which is a known model of hypercholesterolemia. Our aim was to study
this protective effect and to explore possible mechanisms. METHODS AND RESULTS: ApoA–
V+/+ ApoE−/− mice expressing human apolipoprotein A–V (hapoA–V) were generated and
compared to apoE−/− mice. Atherosclerotic aortic sinus lesion area was 70% smaller in …
levels. We hypothesized that expression of apoA–V would inhibit atherogenesis in apoE−/−
mice fed chow diet which is a known model of hypercholesterolemia. Our aim was to study
this protective effect and to explore possible mechanisms. METHODS AND RESULTS: ApoA–
V+/+ ApoE−/− mice expressing human apolipoprotein A–V (hapoA–V) were generated and
compared to apoE−/− mice. Atherosclerotic aortic sinus lesion area was 70% smaller in …