[HTML][HTML] The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient “apoB-48-only” and “apoB-100-only” mice
HL Dichek, K Qian, N Agrawal - Journal of lipid research, 2004 - ASBMB
Hepatic lipase clears plasma cholesterol by lipolytic and nonlipolytic processing of
lipoproteins. We hypothesized that the nonlipolytic processing (known as the bridging
function) clears cholesterol by removing apoB-48-and apoB-100-containing lipoproteins by
whole particle uptake. To test our hypotheses, we expressed catalytically inactive human HL
(ciHL) in LDL receptor deficient" apoB-48-only" and" apoB-100-only" mice. Expression of
ciHL in" apoB-48-only" mice reduced cholesterol by reducing LDL-C (by 54%, 46±6 vs. 19±8 …
lipoproteins. We hypothesized that the nonlipolytic processing (known as the bridging
function) clears cholesterol by removing apoB-48-and apoB-100-containing lipoproteins by
whole particle uptake. To test our hypotheses, we expressed catalytically inactive human HL
(ciHL) in LDL receptor deficient" apoB-48-only" and" apoB-100-only" mice. Expression of
ciHL in" apoB-48-only" mice reduced cholesterol by reducing LDL-C (by 54%, 46±6 vs. 19±8 …