[HTML][HTML] Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice
HL Dichek, SM Johnson, H Akeefe, GT Lo… - Journal of Lipid …, 2001 - ASBMB
To address the role of the noncatalytic ligand function of hepatic lipase (HL) in low density
lipoprotein (LDL) receptor-mediated lipoprotein metabolism, we characterized transgenic
mice lacking the LDL receptor (LDLR) that express either catalytically active (Ldlr−/− HL) or
inactive (Ldlr−/− HL S145G) human HL on both chow and high fat diets and compared them
with nontransgenic Ldlr−/− mice. In mice fed a chow diet, apolipoprotein (apo) B-containing
lipoprotein levels were 40–60% lower in Ldlr−/− HL and Ldlr−/− HL S145G mice than in …
lipoprotein (LDL) receptor-mediated lipoprotein metabolism, we characterized transgenic
mice lacking the LDL receptor (LDLR) that express either catalytically active (Ldlr−/− HL) or
inactive (Ldlr−/− HL S145G) human HL on both chow and high fat diets and compared them
with nontransgenic Ldlr−/− mice. In mice fed a chow diet, apolipoprotein (apo) B-containing
lipoprotein levels were 40–60% lower in Ldlr−/− HL and Ldlr−/− HL S145G mice than in …