[HTML][HTML] Apolipoprotein AV accelerates plasma hydrolysis of triglyceriderich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
M Merkel, B Loeffler, M Kluger, N Fabig… - Journal of biological …, 2005 - ASBMB
Apolipoprotein A5 (APOA5) is associated with differences in triglyceride levels and familial
combined hyperlipidemia. In genetically engineered mice, apoAV plasma levels are
inversely correlated with plasma triglycerides. To elucidate the mechanism by which apoAV
influences plasma triglycerides, metabolic studies and in vitro assays resembling
physiological conditions were performed. In human APOA5 transgenic mice (hAPOA5tr),
catabolism of chylomicrons and very low density lipoprotein (VLDL) was accelerated due to …
combined hyperlipidemia. In genetically engineered mice, apoAV plasma levels are
inversely correlated with plasma triglycerides. To elucidate the mechanism by which apoAV
influences plasma triglycerides, metabolic studies and in vitro assays resembling
physiological conditions were performed. In human APOA5 transgenic mice (hAPOA5tr),
catabolism of chylomicrons and very low density lipoprotein (VLDL) was accelerated due to …