Therapeutic effects of the endothelin receptor antagonist Ro 48-5695 in the TNBS/DNBS rat model of colitis

I Padol, JQ Huang, CM Hogaboam… - European journal of …, 2000 - journals.lww.com
Objective: Endothelins can act as polyfunctional cytokines. It is therefore possible that
endothelins could play an active role in gut inflammation. Elevated levels of endothelin-1
have been reported in ulcerative colitis and Crohn's disease. The aim of this study was to
establish the therapeutic effect of a'new'endothelin receptor antagonist Ro 48-5695 in an
animal model of inflammatory bowel disease. This study compares the effect of Ro 48-5695
on colonic damage induced by two haptens: trinitrobenzenesulphonic (TNBS) or …