Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

Y Kurihara, H Kurihara, H Suzuki, T Kodama… - Nature, 1994 - nature.com
Y Kurihara, H Kurihara, H Suzuki, T Kodama, K Maemura, R Nagai, H Oda, T Kuwaki…
Nature, 1994nature.com
Abstract The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by
homologous recombination to generate mice deficient in ET-1. These ET-1-/-homozygous
mice die of respiratory failure at birth and have morphological abnormalities of the
pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/-heterozygous mice, which
produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These
results suggest that ET-1 is essential for normal mouse development and may also play a …
Abstract
The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/- heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.
nature.com