Combining SDF-1/CXCR4 antagonism and chemotherapy in relapsed acute myeloid leukemia
Leukemia, 2009•nature.com
Hematopoietic stem cell fate has been largely associated with a regulatory environment
commonly referred to as niche. 1 It remains unclear whether this microenvironment in the
bone marrow is located in the endosteal region, the perivasculature or both. 2 Nevertheless,
direct cell–cell contact, soluble factors and extracellular matrix components have been
implicated in the support of hematopoietic stem cells. Interestingly, most of these regulatory
signals have also been associated with
commonly referred to as niche. 1 It remains unclear whether this microenvironment in the
bone marrow is located in the endosteal region, the perivasculature or both. 2 Nevertheless,
direct cell–cell contact, soluble factors and extracellular matrix components have been
implicated in the support of hematopoietic stem cells. Interestingly, most of these regulatory
signals have also been associated with
Hematopoietic stem cell fate has been largely associated with a regulatory environment commonly referred to as niche. 1 It remains unclear whether this microenvironment in the bone marrow is located in the endosteal region, the perivasculature or both. 2 Nevertheless, direct cell–cell contact, soluble factors and extracellular matrix components have been implicated in the support of hematopoietic stem cells. Interestingly, most of these regulatory signals have also been associated with
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