The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma
S Shimizu, T Takehara, H Hikita, T Kodama… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Bcl-xL, an anti-apoptotic member of the Bcl-2 family, is over-
expressed in human hepatocellular carcinoma, conferring a survival advantage to tumour
cells. The mechanisms underlying its dysregulation have not been clarified. In the present
study, we explored the involvement of microRNAs that act as endogenous sequence-
specific suppressors of gene expression. METHODS: The expression profiles of microRNAs
in Huh7 hepatoma cells and primary human hepatocytes were compared by microarray …
expressed in human hepatocellular carcinoma, conferring a survival advantage to tumour
cells. The mechanisms underlying its dysregulation have not been clarified. In the present
study, we explored the involvement of microRNAs that act as endogenous sequence-
specific suppressors of gene expression. METHODS: The expression profiles of microRNAs
in Huh7 hepatoma cells and primary human hepatocytes were compared by microarray …