Lateral organization of endocytic machinery in dendritic spines
Nature neuroscience, 2004•nature.com
Postsynaptic membrane trafficking plays an important role in synaptic plasticity, but the
organization of trafficking machinery within dendritic spines is poorly understood. We use
immunocytochemical analysis of rat hippocampal neurons to show that proteins mediating
endocytosis are systematically arrayed within dendritic spines, tangential to the synapse.
Thus, previously unrecognized lateral domains of the spine organize endocytic protein
machinery at sites removed from the postsynaptic density.
organization of trafficking machinery within dendritic spines is poorly understood. We use
immunocytochemical analysis of rat hippocampal neurons to show that proteins mediating
endocytosis are systematically arrayed within dendritic spines, tangential to the synapse.
Thus, previously unrecognized lateral domains of the spine organize endocytic protein
machinery at sites removed from the postsynaptic density.
Abstract
Postsynaptic membrane trafficking plays an important role in synaptic plasticity, but the organization of trafficking machinery within dendritic spines is poorly understood. We use immunocytochemical analysis of rat hippocampal neurons to show that proteins mediating endocytosis are systematically arrayed within dendritic spines, tangential to the synapse. Thus, previously unrecognized lateral domains of the spine organize endocytic protein machinery at sites removed from the postsynaptic density.
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