Regulation by hypoxia of adrenomedullin output and expression in human trophoblast cells
E Marinoni, K Pacioni, A Sambuchini… - European Journal of …, 2011 - Elsevier
OBJECTIVES: Plasma adrenomedullin concentrations are increased in the fetal circulation
in acute and chronic hypoxic conditions. The effect of hypoxia in regulating adrenomedullin
synthesis and secretion was investigated in human placental trophoblast cells. STUDY
DESIGN: Human trophoblast cells obtained from term placentas (n= 7) were cultured in
hypoxic condition (3% oxygen). Cytotrophoblast cells were cultured for up to 48h and
syncytiotrophoblasts for 2, 8 and 24h. Changes in adrenomedullin output compared to …
in acute and chronic hypoxic conditions. The effect of hypoxia in regulating adrenomedullin
synthesis and secretion was investigated in human placental trophoblast cells. STUDY
DESIGN: Human trophoblast cells obtained from term placentas (n= 7) were cultured in
hypoxic condition (3% oxygen). Cytotrophoblast cells were cultured for up to 48h and
syncytiotrophoblasts for 2, 8 and 24h. Changes in adrenomedullin output compared to …