DNA methylation changes in cells regrowing after fractioned ionizing radiation
BACKGROUND AND PURPOSE: Repeated exposure to ionizing radiation (IR) can result in
adaptive reactions. While DNA methylation changes in adaption to repeated stress exposure
are established for a variety of drugs, their role in fractioned ionizing radiation is largely
unknown. MATERIAL AND METHODS: MCF7 breast cancer cells were treated 5 times a
week with IR in fractions of 2Gy, resulting in total doses of 10 and 20Gy. Cells were
harvested 48 and 72h after the last irradiation, as well as after a recovery period of at least …
adaptive reactions. While DNA methylation changes in adaption to repeated stress exposure
are established for a variety of drugs, their role in fractioned ionizing radiation is largely
unknown. MATERIAL AND METHODS: MCF7 breast cancer cells were treated 5 times a
week with IR in fractions of 2Gy, resulting in total doses of 10 and 20Gy. Cells were
harvested 48 and 72h after the last irradiation, as well as after a recovery period of at least …