Angiotensin II content in the kidney is much higher than in the plasma, and it increases more
in kidney diseases through an uncertain mechanism. Because the kidney abundantly
expresses angiotensinogen mRNA, transcriptional dysregulation of angiotensinogen within
the kidney is one potential cause of increased renal angiotensin II in the setting of disease.
Here, we observed that kidney-specific angiotensinogen knockout mice had levels of renal
angiotensinogen protein and angiotensin II that were similar to those levels of control mice …