PTPN22: Its role in SLE and autoimmunity
SA Chung, LA Criswell - Autoimmunity, 2007 - Taylor & Francis
Autoimmunity, 2007•Taylor & Francis
A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently
been shown to be associated with multiple autoimmune diseases, including systemic lupus
erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid
disease. In this review, we discuss the structure and function of this gene and its disease-
associated polymorphisms. In addition, we review the studies investigating the association
between this gene and SLE, along with other autoimmune diseases.
been shown to be associated with multiple autoimmune diseases, including systemic lupus
erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid
disease. In this review, we discuss the structure and function of this gene and its disease-
associated polymorphisms. In addition, we review the studies investigating the association
between this gene and SLE, along with other autoimmune diseases.
A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. In this review, we discuss the structure and function of this gene and its disease-associated polymorphisms. In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases.
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