Neuregulin-1 (NRG-1), a cardioactive growth factor released from endothelial cells, has
been shown to be indispensable for the normal function of the adult heart by binding to
ErbB4 receptors on cardiomyocytes. In the present study, we have investigated to what
extent ErbB2, the favored co-factor of ErbB4 for heterodimerization, participates in the
cardiac effects of endothelium-derived NRG-1. In addition, in view of our previously
described anti-adrenergic effects of NRG-1, we have studied which neurohormonal stimuli …