Recovery from postpartum cardiomyopathy in 2 patients by blocking prolactin release with bromocriptine
D Hilfiker-Kleiner, GP Meyer, E Schieffer… - Journal of the American …, 2007 - jacc.org
D Hilfiker-Kleiner, GP Meyer, E Schieffer, B Goldmann, E Podewski, I Struman, P Fischer…
Journal of the American College of Cardiology, 2007•jacc.orgDiscussion Experimental data implicate a causal role of the 16 kDa prolactin for the
development of PPCM in mice, which was prevented by suppression of prolactin secretion
with bromocriptine before the onset of the disease (3). Similarly, in a small pilot study,
bromocriptine prevented the recurrence of PPCM in a subsequent pregnancy in women who
survived PPCM in the previous pregnancy (3).
development of PPCM in mice, which was prevented by suppression of prolactin secretion
with bromocriptine before the onset of the disease (3). Similarly, in a small pilot study,
bromocriptine prevented the recurrence of PPCM in a subsequent pregnancy in women who
survived PPCM in the previous pregnancy (3).
Discussion
Experimental data implicate a causal role of the 16 kDa prolactin for the development of PPCM in mice, which was prevented by suppression of prolactin secretion with bromocriptine before the onset of the disease (3). Similarly, in a small pilot study, bromocriptine prevented the recurrence of PPCM in a subsequent pregnancy in women who survived PPCM in the previous pregnancy (3).
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