Multicolor spectral karyotyping of human chromosomes
E Schröck, S Du Manoir, T Veldman, B Schoell… - Science, 1996 - science.org
E Schröck, S Du Manoir, T Veldman, B Schoell, J Wienberg, MA Ferguson-Smith, Y Ning…
Science, 1996•science.orgThe simultaneous and unequivocal discernment of all human chromosomes in different
colors would be of significant clinical and biologic importance. Whole-genome scanning by
spectral karyotyping allowed instantaneous visualization of defined emission spectra for
each human chromosome after fluorescence in situ hybridization. By means of computer
separation (classification) of spectra, spectrally overlapping chromosome-specific DNA
probes could be resolved, and all human chromosomes were simultaneously identified.
colors would be of significant clinical and biologic importance. Whole-genome scanning by
spectral karyotyping allowed instantaneous visualization of defined emission spectra for
each human chromosome after fluorescence in situ hybridization. By means of computer
separation (classification) of spectra, spectrally overlapping chromosome-specific DNA
probes could be resolved, and all human chromosomes were simultaneously identified.
The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were simultaneously identified.
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