Aminophospholipid translocase and proteins involved in transmembrane phospholipid traffic
D Dolis, C Moreau, A Zachowski, PF Devaux - Biophysical chemistry, 1997 - Elsevier
The transmembrane distribution of phospholipids in the membranes of eukaryotic cells
depends on specific proteins (called flippases). The aminophospholipid translocase is
responsible for the sequestration of phosphatidylserine and phosphatidylethanolamine in
the cytosolic leaflet of plasma membranes. Several laboratories are presently working on the
identification, purification and cloning of this Mg-ATPase, first recognized in the human red
cell membrane. In accordance with the 1992 hypothesis of Higgins and Gottesman, proteins …
depends on specific proteins (called flippases). The aminophospholipid translocase is
responsible for the sequestration of phosphatidylserine and phosphatidylethanolamine in
the cytosolic leaflet of plasma membranes. Several laboratories are presently working on the
identification, purification and cloning of this Mg-ATPase, first recognized in the human red
cell membrane. In accordance with the 1992 hypothesis of Higgins and Gottesman, proteins …