Hypoxia-inducible factors 1α and 2α are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
A Giatromanolaki, E Sivridis, C Kouskoukis… - Melanoma …, 2003 - journals.lww.com
Hypoxia is a key regulatory factor in tumour growth, activating angiogenesis, glycolysis and
cell migration. It is readily recognized by the intracellular accumulation of hypoxia-inducible
factor 1α (HIF1α) and HIF2α. Accumulation of HIF1α and HIF2α was detected
immunohistochemically in a series of 46 nodular malignant melanomas of the skin
(epithelioid cell variant), treated with wide local excision. The results were correlated with
vascular density (VD) and expression of the angiogenesis-stimulating factors vascular …
cell migration. It is readily recognized by the intracellular accumulation of hypoxia-inducible
factor 1α (HIF1α) and HIF2α. Accumulation of HIF1α and HIF2α was detected
immunohistochemically in a series of 46 nodular malignant melanomas of the skin
(epithelioid cell variant), treated with wide local excision. The results were correlated with
vascular density (VD) and expression of the angiogenesis-stimulating factors vascular …