Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors
Poorly differentiated neuroendocrine carcinomas (NECs) of the pancreas are rare malignant
neoplasms with a poor prognosis. The aim of this study was to determine the
clinicopathologic and genetic features of poorly differentiated NECs and compare them with
other types of pancreatic neoplasms. We investigated alterations of KRAS, CDKN2A/p16,
TP53, SMAD4/DPC4, DAXX, ATRX, PTEN, Bcl2, and RB1 by immunohistochemistry and/or
targeted exomic sequencing in surgically resected specimens of 9 small cell NECs, 10 large …
neoplasms with a poor prognosis. The aim of this study was to determine the
clinicopathologic and genetic features of poorly differentiated NECs and compare them with
other types of pancreatic neoplasms. We investigated alterations of KRAS, CDKN2A/p16,
TP53, SMAD4/DPC4, DAXX, ATRX, PTEN, Bcl2, and RB1 by immunohistochemistry and/or
targeted exomic sequencing in surgically resected specimens of 9 small cell NECs, 10 large …