[HTML][HTML] p62 at the crossroads of autophagy, apoptosis, and cancer
J Moscat, MT Diaz-Meco - Cell, 2009 - cell.com
Cell, 2009•cell.com
The signaling adaptor p62 is a multidomain protein implicated in the activation of the
transcription factor NF-κB. Recent findings link p62 activity to the extrinsic apoptosis
pathway, and Mathew et al.(2009) now show that the modulation of p62 by autophagy is a
key factor in tumorigenesis. These findings place p62 at critical decision points that control
cell death and survival.
transcription factor NF-κB. Recent findings link p62 activity to the extrinsic apoptosis
pathway, and Mathew et al.(2009) now show that the modulation of p62 by autophagy is a
key factor in tumorigenesis. These findings place p62 at critical decision points that control
cell death and survival.
The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-κB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.
cell.com