The pathogenesis of allergic asthma involves the interplay of inflammatory cells and resident
airway cells, and of their secreted mediators including cytokines, chemokines, growth factors
and inflammatory mediators. Tyrosine kinase signaling cascades play a critical role in the
pathogenesis of allergic airway inflammation. Receptor tyrosine kinases (eg epidermal
growth factor receptor [EGFR] and platelet-derived growth factor receptor) are important for
the pathogenesis of airway remodeling. Stimulation of non-receptor tyrosine kinases (eg …