[HTML][HTML] The human L (3) MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)

P Boccuni, D MacGrogan, JM Scandura… - Journal of Biological …, 2003 - ASBMB
HL (3) MBT, the human homolog of theDrosophila lethal (3) malignant brain tumor protein, is
a member of the polycomb group (PcG) of proteins, which function as transcriptional
regulators in large protein complexes. Homozygous mutations in the l (3) mbt gene cause
brain tumors inDrosophila, identifying l (3) mbt as a tumor suppressor gene. The hl (3) mbt
gene maps to chromosome 20q12, within a common deleted region associated with myeloid
hematopoietic malignancies. HL (3) MBT contains three repeats of 100 residues called MBT …