A comparison of 13C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-13C] …
GF Mason, KF Petersen, RA de Graaf… - Brain Research …, 2003 - Elsevier
13C-labeled glucose is increasingly used in conjunction with magnetic resonance
spectroscopy to measure rates of metabolic pathways in the brain in vivo. Most studies of
human subjects have used intravenous infusions to administer the labeled compounds, but
the procedure is cumbersome and can be uncomfortable for patients with neurological or
psychiatric disorders. It may be possible to improve the practicality of the method by
administering the glucose orally instead of intravenously. This report describes the …
spectroscopy to measure rates of metabolic pathways in the brain in vivo. Most studies of
human subjects have used intravenous infusions to administer the labeled compounds, but
the procedure is cumbersome and can be uncomfortable for patients with neurological or
psychiatric disorders. It may be possible to improve the practicality of the method by
administering the glucose orally instead of intravenously. This report describes the …