Th17 cells regulate liver fibrosis by targeting multiple cell types: many birds with one stone
Naïve CD4+ T cells are activated via their T-cell receptor when it interacts with a major
histocompatibility complex–peptide complex on an antigen presenting cell, followed by
differentiation into T helper (Th) 1, Th2, Th17, or regulatory T cells (Treg), depending on
which cytokines are present during activation. 1 Specifically, if naïve CD4+ T cells are
activated in an environment rich in interleukin (IL)-12, the expression of the transcription
factor T-beta is induced, followed by initiating a sequence of events that lead to …
histocompatibility complex–peptide complex on an antigen presenting cell, followed by
differentiation into T helper (Th) 1, Th2, Th17, or regulatory T cells (Treg), depending on
which cytokines are present during activation. 1 Specifically, if naïve CD4+ T cells are
activated in an environment rich in interleukin (IL)-12, the expression of the transcription
factor T-beta is induced, followed by initiating a sequence of events that lead to …