Mechanisms of disease progression in NASH: new paradigms
BN Bohinc, AM Diehl - Clinics in liver disease, 2012 - liver.theclinics.com
Nonalcoholic fatty liver disease (NAFLD) and its more serious form, nonalcoholic
steatohepatitis (NASH), are the hepatic manifestations of obesity and the metabolic
syndrome. 1 NAFLD is currently the leading cause of chronic liver disease, with a
prevalence estimated to affect nearly 30% of the US population. 2 According to the latest
figures, NASH affects 2% to 5% of all Americans. 3 Interpatient variability in manifestations of
the disease is apparent; some progress to fibrosis, cirrhosis, and, ultimately,
steatohepatitis (NASH), are the hepatic manifestations of obesity and the metabolic
syndrome. 1 NAFLD is currently the leading cause of chronic liver disease, with a
prevalence estimated to affect nearly 30% of the US population. 2 According to the latest
figures, NASH affects 2% to 5% of all Americans. 3 Interpatient variability in manifestations of
the disease is apparent; some progress to fibrosis, cirrhosis, and, ultimately,