Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B
YO Kweon, ZD Goodman, JL Dienstag, ER Schiff… - Journal of …, 2001 - Elsevier
Background: Activation of hepatic stellate cells is the earliest step in fibrogenesis. Alpha-
smooth muscle actin (α-SMA), expressed by activated hepatic stellate cells, and C-terminal
procollagen α1 (III) propeptide (PIIICP) are early markers of fibrogenesis and should
precede fibrosis. Aim: Determine if suppression of hepatitis B virus replication with
lamivudine would decrease fibrogenesis as measured by immunohistochemical markers.
Methods: Paired liver biopsies from patients with hepatitis B before and after therapy with …
smooth muscle actin (α-SMA), expressed by activated hepatic stellate cells, and C-terminal
procollagen α1 (III) propeptide (PIIICP) are early markers of fibrogenesis and should
precede fibrosis. Aim: Determine if suppression of hepatitis B virus replication with
lamivudine would decrease fibrogenesis as measured by immunohistochemical markers.
Methods: Paired liver biopsies from patients with hepatitis B before and after therapy with …