Following hepatic injury, proliferation of anastomosing ductules can be observed. The origin
of this ductular reaction is not completely clear, although there is considerable evidence for
proliferation of a putative hepatic progenitor cell, reported to be located in the canals of
Hering (CoH) and showing morphologic similarities with rat oval cells. In this study, we
analyzed the immunophenotype of solitary oval cell-like cells (SOC), intralobular groups of
cuboidal cells that might represent lining cells of CoH, bile ductular cells (BDC), bile duct …