Background/Aims/Methods: Since in rat experiments, activation of progenitor cells is seen in
conditions associated with hepatocyte injury or inhibited replication, we compared the
activation and fate of human putative progenitor cells in regenerating liver versus chronic
cholestatic disease, using immunohistochemistry, rat oval cell marker OV6 and a panel of
bile ductular rat models: the choline-deficient acetylaminofluorene (CDAAF)-and alpha-
napthylisothiocyanate (ANIT)-model, using immunohistochemistry and electron microscopy …