Solid tumors are thought to contain cancer stem cells (CSCs) as a distinct population
responsible for tumor relapse and metastasis due to their abilities to self-renew, differentiate,
and give rise to a new tumor in local or distant organs. CSCs have been identified in many
tumor types, including hepatocellular carcinoma (HCC), the fifth most common and third
most deadly malignancy with observable heterogeneity. Numerous studies have shown that
hepatic CSCs could be enriched via different cell surface markers, eg, CD13, CD24, CD44 …