[HTML][HTML] Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver …
A Budhu, M Forgues, QH Ye, HL Jia, P He, KA Zanetti… - Cancer cell, 2006 - cell.com
A Budhu, M Forgues, QH Ye, HL Jia, P He, KA Zanetti, US Kammula, Y Chen, LX Qin…
Cancer cell, 2006•cell.comHepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or
postsurgical recurrence. We postulate that metastases are influenced by the liver
microenvironment. Here, we show that a unique inflammation/immune response-related
signature is associated with noncancerous hepatic tissues from metastatic HCC patients.
This signature is principally different from that of the tumor. A global Th1/Th2-like cytokine
shift in the venous metastasis-associated liver microenvironment coincides with elevated …
postsurgical recurrence. We postulate that metastases are influenced by the liver
microenvironment. Here, we show that a unique inflammation/immune response-related
signature is associated with noncancerous hepatic tissues from metastatic HCC patients.
This signature is principally different from that of the tumor. A global Th1/Th2-like cytokine
shift in the venous metastasis-associated liver microenvironment coincides with elevated …
Summary
Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or postsurgical recurrence. We postulate that metastases are influenced by the liver microenvironment. Here, we show that a unique inflammation/immune response-related signature is associated with noncancerous hepatic tissues from metastatic HCC patients. This signature is principally different from that of the tumor. A global Th1/Th2-like cytokine shift in the venous metastasis-associated liver microenvironment coincides with elevated expression of macrophage colony-stimulating factor (CSF1). Moreover, a refined 17 gene signature was validated as a superior predictor of HCC venous metastases in an independent cohort, when compared to other clinical prognostic parameters. We suggest that a predominant humoral cytokine profile occurs in the metastatic liver milieu and that a shift toward anti-inflammatory/immune-suppressive responses may promote HCC metastases.
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