Salvage effect of the vascular endothelial growth factor on chemically induced acute severe liver injury in rats
T Namisaki, H Yoshiji, H Kojima, J Yoshii, Y Ikenaka… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: The role of the vascular endothelial growth factor (VEGF), a potent
angiogenic factor, in liver regeneration following acute severe liver injury (ALI) has not been
elucidated. The aims of the current study were to investigate the role of VEGF, and to find out
whether VEGF can improve the outcome of ALI in rats. METHODS: ALI was induced in male
rats by combination of d-galactosamine (Gal-N) and lipopolysaccharide (LPS). The survival
rate and several indices were chronologically compared with or without VEGF treatment …
angiogenic factor, in liver regeneration following acute severe liver injury (ALI) has not been
elucidated. The aims of the current study were to investigate the role of VEGF, and to find out
whether VEGF can improve the outcome of ALI in rats. METHODS: ALI was induced in male
rats by combination of d-galactosamine (Gal-N) and lipopolysaccharide (LPS). The survival
rate and several indices were chronologically compared with or without VEGF treatment …