[HTML][HTML] Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts
Endogenous glucocorticoids (GCs) and inflammatory cytokines contribute to the age-
associated loss of bone mass and strength, but the molecular mechanisms responsible for
their deleterious effects on the aging skeleton are unclear. Based on evidence that oxidative
stress is a causal mechanism of the insulin resistance produced by either one of these two
agents, we tested the hypothesis that their adverse skeletal effects also result from increased
oxidative stress. We report that administration of prednisolone to mice increased reactive …
associated loss of bone mass and strength, but the molecular mechanisms responsible for
their deleterious effects on the aging skeleton are unclear. Based on evidence that oxidative
stress is a causal mechanism of the insulin resistance produced by either one of these two
agents, we tested the hypothesis that their adverse skeletal effects also result from increased
oxidative stress. We report that administration of prednisolone to mice increased reactive …