[HTML][HTML] Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis
A Sommerfeld, R Reinehr, D Häussinger - Journal of biological chemistry, 2009 - ASBMB
Bile acids have been reported to induce epidermal growth factor receptor (EGFR) activation
and subsequent proliferation of activated hepatic stellate cells (HSC), but the underlying
mechanisms and whether quiescent HSC are also a target for bile acid-induced proliferation
or apoptosis remained unclear. Therefore, primary rat HSC were cultured for up to 48 h and
analyzed for their proliferative/apoptotic responses toward bile acids. Hydrophobic bile
acids, ie taurolithocholate 3-sulfate, taurochenodeoxycholate, and glycochenodeoxycholate …
and subsequent proliferation of activated hepatic stellate cells (HSC), but the underlying
mechanisms and whether quiescent HSC are also a target for bile acid-induced proliferation
or apoptosis remained unclear. Therefore, primary rat HSC were cultured for up to 48 h and
analyzed for their proliferative/apoptotic responses toward bile acids. Hydrophobic bile
acids, ie taurolithocholate 3-sulfate, taurochenodeoxycholate, and glycochenodeoxycholate …