[HTML][HTML] Physiologic and pharmacologic factors influencing glyceroneogeniccontribution to triacylglyceride glycerol measured by mass isotopomerdistribution analysis
An imbalance between triacylglycerol synthesis and breakdown is necessaryfor the
development of obesity. The direct precursor for triacylglycerolbiosynthesis is α-glycerol
phosphate, which can have glycolytic andglyceroneogenic origins. We present a technique
for determining the relativeglyceroneogenic contribution to triacylglyceride glycerol by
labeling theglycerol moiety with 2 H 2 O. The number of hydrogen atoms (n) incorporated
from H 2 O into C–H bonds reflectsthe metabolic source of α-glycerol phosphate and can be …
development of obesity. The direct precursor for triacylglycerolbiosynthesis is α-glycerol
phosphate, which can have glycolytic andglyceroneogenic origins. We present a technique
for determining the relativeglyceroneogenic contribution to triacylglyceride glycerol by
labeling theglycerol moiety with 2 H 2 O. The number of hydrogen atoms (n) incorporated
from H 2 O into C–H bonds reflectsthe metabolic source of α-glycerol phosphate and can be …