Mice Harboring a Defective Epidermal Growth Factor Receptor-(Waved-2) Have an Increased Susceptibility to Acute Dextran-Sulfate-induced Colitis

B Egger, MW Büchler, J Lakshmanan… - Scandinavian journal …, 2000 - Taylor & Francis
B Egger, MW Büchler, J Lakshmanan, P Moore, VE Eysselein
Scandinavian journal of gastroenterology, 2000Taylor & Francis
Background: It has been reported that epithelial growth factor (EGF) and transforming growth
factor-alpha (TGF-alpha) play an important role in colonic mucosal defense and repair.
Waved-2 (wa-2) mice harboring a defect EGF-R and phenotypically similar to TGF-alpha
knockout mice provide a novel approach to study the role of EGF-R ligands in the
maintenance and repair of colonic mucosa. Methods: Acute colonic mucosal injury was
induced by oral administration of dextran sodium sulfate (DSS: 5 g%) given for 6 days ad …
Background: It has been reported that epithelial growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) play an important role in colonic mucosal defense and repair. Waved-2 (wa-2) mice harboring a defect EGF-R and phenotypically similar to TGF-alpha knockout mice provide a novel approach to study the role of EGF-R ligands in the maintenance and repair of colonic mucosa. Methods: Acute colonic mucosal injury was induced by oral administration of dextran sodium sulfate (DSS: 5 g%) given for 6 days ad libitum to wa-2 homozygotes and their genetic controls (n
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