[HTML][HTML] The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes: implications for cutaneous disease

AP Kowalczyk, M Hatzfeld, EA Bornslaeger… - Journal of Biological …, 1999 - ASBMB
The contribution of desmosomes to epidermal integrity is evident in the inherited blistering
disorder associated with the absence of a functional gene for plakophilin-1. To define the
function of plakophilin-1 in desmosome assembly, interactions among the desmosomal
cadherins, desmoplakin, and the armadillo family members plakoglobin and plakophilin-1
were examined. In transient expression assays, plakophilin-1 formed complexes with a
desmoplakin amino-terminal domain and enhanced its recruitment to cell-cell borders; this …