Poly I: C prevents T cell-mediated hepatitis via an NK-dependent mechanism
J Wang, R Sun, H Wei, Z Dong, B Gao, Z Tian - Journal of hepatology, 2006 - Elsevier
BACKGROUND/AIMS: T cell immune responses play key roles in the pathogenesis of viral
hepatitis, and innate immunity is known to be also activated during this process, however,
the effects of innate immunity activation on T cell-mediated hepatitis remain obscure. Here
we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3)
ligand, polyinosinic–polycytidylic acid (poly I: C), on concanavalin A (Con A)-induced T cell-
mediated liver injury. METHODS: Mice received nontoxic intraperitoneal poly I: C injection …
hepatitis, and innate immunity is known to be also activated during this process, however,
the effects of innate immunity activation on T cell-mediated hepatitis remain obscure. Here
we examined the effect of the activation of NK cells induced by toll-like receptor 3 (TLR3)
ligand, polyinosinic–polycytidylic acid (poly I: C), on concanavalin A (Con A)-induced T cell-
mediated liver injury. METHODS: Mice received nontoxic intraperitoneal poly I: C injection …