[HTML][HTML] Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells

K Nagao, K Takahashi, K Hanada, N Kioka… - Journal of biological …, 2007 - ASBMB
ATP binding cassette protein A1 (ABCA1) plays a major role in cholesterol homeostasis and
high density lipoprotein (HDL) metabolism. It is proposed that ABCA1 reorganizes the
plasma membrane and generates more loosely packed domains that facilitate apoA-I-
dependent cholesterol efflux. In this study, we examined the effects of the cellular
sphingomyelin level on HDL formation by ABCA1 by using a Chinese hamster ovary-K1
mutant cell line, LY-A, which has a missense mutation in the ceramide transfer protein …