Lipid raft microdomains mediate class A scavenger receptor-dependent infection of Brucella abortus
S Kim, M Watarai, H Suzuki, S Makino, T Kodama… - Microbial …, 2004 - Elsevier
Brucella abortus is a facultative intracellular bacterium that can survive inside macrophages.
Intracellular replication of B. abortus requires the VirB complex, which is highly similar to the
conjugative DNA transfer system. In this study, we showed that a class A scavenger receptor
(SR-A) of macrophages is required to internalize B. abortus and contributes to the
establishment of bacterial infection in mice. Macrophages from SR-A-deficient mice inhibited
internalization and intracellular replication of both wild type strain and the virB4 mutant, and …
Intracellular replication of B. abortus requires the VirB complex, which is highly similar to the
conjugative DNA transfer system. In this study, we showed that a class A scavenger receptor
(SR-A) of macrophages is required to internalize B. abortus and contributes to the
establishment of bacterial infection in mice. Macrophages from SR-A-deficient mice inhibited
internalization and intracellular replication of both wild type strain and the virB4 mutant, and …