[HTML][HTML] The islet β cell-enriched MafA activator is a key regulator of insulin gene transcription
L Zhao, M Guo, T Matsuoka, DK Hagman… - Journal of Biological …, 2005 - ASBMB
The islet-enriched MafA, PDX-1, and BETA2 activators contribute to both β cell-specific and
glucose-responsive insulin gene transcription. To investigate how these factors impart
activation, their combined impact upon insulin enhancer-driven expression was first
examined in non-β cell line transfection assays. Individual expression of PDX-1 and BETA2
led to little or no activation, whereas MafA alone did so modestly. MafA together with PDX-1
or BETA2 produced synergistic activation, with even higher insulin promoter activity found …
glucose-responsive insulin gene transcription. To investigate how these factors impart
activation, their combined impact upon insulin enhancer-driven expression was first
examined in non-β cell line transfection assays. Individual expression of PDX-1 and BETA2
led to little or no activation, whereas MafA alone did so modestly. MafA together with PDX-1
or BETA2 produced synergistic activation, with even higher insulin promoter activity found …