Glycogen synthase kinase 3 in the world of cell migration

T Sun, M Rodriguez, L Kim - Development, growth & …, 2009 - Wiley Online Library
T Sun, M Rodriguez, L Kim
Development, growth & differentiation, 2009Wiley Online Library
Glycogen synthase kinase 3 (GSK3) is one of the few master switch kinases that regulate
many aspects of cell functions. Recent studies on cell polarization and migration have
shown that GSK3 is also essential for proper regulation of these processes. GSK3 influences
cell migration as one of the regulators of the spatiotemporally controlled dynamics of the
actin cytoskeleton, microtubules, and cell‐to‐matrix adhesions. In this mini‐review, the
effects of GSK3 on these three aspects of cell migration will be discussed.
Glycogen synthase kinase 3 (GSK3) is one of the few master switch kinases that regulate many aspects of cell functions. Recent studies on cell polarization and migration have shown that GSK3 is also essential for proper regulation of these processes. GSK3 influences cell migration as one of the regulators of the spatiotemporally controlled dynamics of the actin cytoskeleton, microtubules, and cell‐to‐matrix adhesions. In this mini‐review, the effects of GSK3 on these three aspects of cell migration will be discussed.
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