Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses
I Migeotte, D Communi, M Parmentier - Cytokine & growth factor reviews, 2006 - Elsevier
The formyl peptide receptor (FPR) family is involved in host defence against pathogens, but
also in sensing internal molecules that may constitute signals of cellular dysfunction. It
includes three subtypes in human and other primates. FPR responds to formyl peptides
derived from bacterial and mitochondrial proteins. FPRL1 displays a large array of
exogenous and endogenous ligands, including the chemokine variant sCKβ8-1, the
neuroprotective peptide humanin, and lipoxin A4. Two high affinity agonists (F2L and …
also in sensing internal molecules that may constitute signals of cellular dysfunction. It
includes three subtypes in human and other primates. FPR responds to formyl peptides
derived from bacterial and mitochondrial proteins. FPRL1 displays a large array of
exogenous and endogenous ligands, including the chemokine variant sCKβ8-1, the
neuroprotective peptide humanin, and lipoxin A4. Two high affinity agonists (F2L and …