The actin cytoskeleton: a key regulator of apoptosis and ageing?
CW Gourlay, KR Ayscough - Nature reviews Molecular cell biology, 2005 - nature.com
Nature reviews Molecular cell biology, 2005•nature.com
Evidence from many organisms has shown that the accumulation of reactive oxygen species
(ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to
programmed cell death pathways and to ageing. Recent reports have implicated changes to
the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and
subsequent cell death.
(ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to
programmed cell death pathways and to ageing. Recent reports have implicated changes to
the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and
subsequent cell death.
Abstract
Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.
nature.com