[HTML][HTML] Differential modulation of human melanoma cell metalloproteinase expression by α2β1 integrin and CD44 triple-helical ligands derived from type IV collagen
D Baronas-Lowell, JL Lauer-Fields, JA Borgia… - Journal of Biological …, 2004 - ASBMB
Tumor cell binding to components of the basement membrane is well known to trigger
intracellular signaling pathways. Signaling ultimately results in the modulation of gene
expression, facilitating metastasis. Type IV collagen is the major structural component of the
basement membrane and is known to be a polyvalent ligand, possessing sequences bound
by the α 1 β 1, α 2 β 1, and α 3 β 1 integrins, as well as cell surface proteoglycan receptors,
such as CD44/chondroitin sulfate proteoglycan (CSPG). The role of α 2 β 1 integrin and …
intracellular signaling pathways. Signaling ultimately results in the modulation of gene
expression, facilitating metastasis. Type IV collagen is the major structural component of the
basement membrane and is known to be a polyvalent ligand, possessing sequences bound
by the α 1 β 1, α 2 β 1, and α 3 β 1 integrins, as well as cell surface proteoglycan receptors,
such as CD44/chondroitin sulfate proteoglycan (CSPG). The role of α 2 β 1 integrin and …