[HTML][HTML] The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation
F Edwin, R Singh, R Endersby, SJ Baker… - Journal of Biological …, 2006 - ASBMB
Sprouty family proteins are novel regulators of growth factor actions. Human Sprouty 2
(hSPRY2) inhibits the proliferation of a number of different cell types. However, the
mechanisms involved in the anti-proliferative actions of hSPRY2 remain to be elucidated.
Here we have demonstrated that hSPRY2 increases the amount of the tumor suppressor
phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and decreases its
phosphorylation. The resultant increase in PTEN activity is reflected in decreased activation …
(hSPRY2) inhibits the proliferation of a number of different cell types. However, the
mechanisms involved in the anti-proliferative actions of hSPRY2 remain to be elucidated.
Here we have demonstrated that hSPRY2 increases the amount of the tumor suppressor
phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and decreases its
phosphorylation. The resultant increase in PTEN activity is reflected in decreased activation …